These are the sources and citations used to research huntington s disease. Huntingtons disease is a genetically inherited condition which results in severe nervecell damage in the brain. Sportsman is a staff nurse in the medical psychiatric program and elizabeth l. Huntingtons disease core concepts and current advances. This includes both faulty voluntary actions and involuntary movements like jerking movements or trembling chorea.
We proposed to assess the effectiveness of interventions aimed at modifying disease progression and evaluate the methodological quality of the corresponding clinical trials. Huntingtons disease is a neurodegenerative condition and a person with this disorder will face difficulties in motor functions, cognitive deterioration, and psychiatric symptoms. Traditionally, this condition was known as huntington chorea. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Huntingtons disease is one of the wellstudied neurodegenerative conditions, a quite devastating and currently incurable one.
An evidencebased approach in the treatment of huntington. Huntington s disease has a broad impact on a persons functional abilities and usually results in movement, thinking cognitive and psychiatric disorders. Huntingtons disease is an inherited disease that causes the progressive breakdown degeneration of nerve cells in the brain. Huntingtons disease is a disease that is passed from generation to generation and is associated with progressive degeneration of nerve cells in the brain. It really serves to demonstrate how beneficial a good longitudinal study can be.
Regional and cellular gene expression changes in human huntingtons disease brain. Huntingtons disease hd is an inherited disease that causes certain nerve cells in the brain to waste away. Huntingtons disease can attack just about anyone, but it is involved in the genetics of a family. Huntingtons disease hd is a neurodegenerative genetic disorder that affects muscle coordination and leads to mental decline and behavioral disorders.
The company said huntington disease hd is a rare and fatal neurodegenerative disorder caused by the progressive breakdown of nerve cells in the brain that affects about five to seven people per 100,000 in western countries. Huntington disease huntington disease hd is an inherited progressive brain disease. Since the mutation has multiple effects in the cell and the precise mechanism of the. The affected areas of degeneration are the basal ganglia, which play an important role in the control of movement. This study aimed to gain a better understanding of behavioral abnormalities in huntington disease hd and to develop a method for reliably assessing these changes. A general lack of coordination and an unsteady gait often follow. Neurobiology of huntingtons disease ncbi bookshelf. Citation machine helps students and professionals properly credit the information that they use. Huntingtons disease symptoms and causes mayo clinic. Huntingtons disease has a broad impact on a persons functional abilities and usually results in movement, thinking cognitive and. Publications product categories huntingtons disease. List of books and articles about huntingtons disease.
Huntingtons disease other bibliographies cite this for me. Behavioral changes are a central feature of hd and often cause considerable distress and difficulty to patients and their relatives. This bibliography was generated on cite this for me on thursday, may 12, 2016. Huntington disease hd is an autosomaldominant disorder, characterized as disease of progressive brain degeneration in late adulthood with subsequent brain atrophy. Huntington s disease, often abbreviated as hd, is a brain disease that causes nerve cells in the brain to deteriorate. We selected eight trials comprising a total of 66 participants.
Huntingtons disease hd is a hereditary and progressive brain disorder. Huntington disease genetic and rare diseases information. It is about creating awareness and giving the families affected by huntingtons disease a voice to a situation that few understand including friends, family, co. Scan your paper for grammar mistakes and catch unintentional plagiarism.
Huntingtons disease offers introduces this disease, detailing its history and progression, and discusses the search for the gene that. Huntingtons disease news is strictly a news and information website about the disease. The journal of huntingtons disease is an international multidisciplinary journal to facilitate progress in understanding the genetics, molecular correlates, pathogenesis, pharmacology, diagnosis and treatment of huntingtons disease and related disorders. The causative gene for huntingtons disease, hd, one of the first genes identified to cause an inherited disease, is located on chromosome 4. Data of 35 consecutive patients tested from 2007 to 2012 at the human genetics unit, faculty of medicine, university of colombo was analyzed. Brenda kelley kim while there are many neurodegenerative diseases that can devastate patients and families, huntingtons disease remains one of the more severe conditions to impact the brain, and, in turn, the lives of family members and patients who must deal with it.
The aim of the guide is to help carers and healthcare staff recognise and respond to the wide ranging symptoms of huntingtons, which affect the way people think, feel, speak, move, swallow and eat. Huntingtons disease hd, also known as huntingtons chorea, is an inherited disorder that results in the death of brain cells. If you read george huntingtons original paper on the disease from back in 1872, his description of the condition remains pretty much spot on as to how the disease is described today. The neurodegeneration in hd is also caused by aberrant immune response in the presence. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The study describes the clinical and genetic characteristics of patients with huntington disease in sri lanka. Huntingtons disease, hereditary, acute disturbance of the central nervous system usually beginning in middle age and characterized by involuntary muscular movements and progressive intellectual deterioration. Huntington disease is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability cognition adultonset huntington disease, the most common form of this disorder, usually appears in a persons thirties or forties. Huntington disease article about huntington disease by. Hd was originally known as huntington s chorea, coming from a greek word meaning to dance, which describes some symptoms of hd. Clinical and genetic features of huntington disease in sri. Pestka is a clinical nurse specialist and an assistant professor of nursing at the mayo.
Huntingtons disease, or huntingtons chorea, is a progressive genetic disease marked by death of brain cells coupled with loss of muscular control and coordination, declining mental abilities, and erratic behavior. Always seek the advice of your physician or other qualified health provider with any. Huntington disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinicalresearch specialists looking to expand their knowledge base of huntington disease information, as well as solid groundwork for advanced students from various backgrounds neurology, psychiatry, neuropsychology, genetics. This book is the authors journey as wife, mother, breadwinner, caregiver and widowspouse survivor of huntingtons disease. We have collaborated with st andrews healthcare to launch a mini guide to understanding the effects of huntingtons disease. Signs and symptoms usually develop between ages 35 to 44 years and may include uncontrolled movements, loss of intellectual abilities, and various emotional and psychiatric problems. Learn vocabulary, terms, and more with flashcards, games, and other study tools. This bibliography was generated on cite this for me on saturday, february 28, 2015. Behavioural change in huntingtons disease citation. Although all family members will not be affected physically, everyone will be affected emotionally, socially, and very often financially. The earliest symptoms are often subtle problems with mood or mental abilities. Ambrose university march 21, 2011 huntingtons disease huntingtons disease is a devastating and progressive neurological disorder that results primarily from degeneration of nerve cells deep in the center of the brain that waste away pubmed health, 2011. Huntingtons disease and laboratory investigation of this disease.
Huntington s disease is a rare, inherited disease that causes the progressive breakdown degeneration of nerve cells in the brain. Huntington disease hd is an autosomal dominantly inherited disease that exhibits genetic anticipation of affected progeny due to expansions of a trinucleotide repeat tnr region within the htt. People are born with the defective gene, but symptoms usually dont appear until middle age. Although symptoms may first show up in midlife, huntingtons can strike anyone. Huntingtons disease hd is a progressive neurodegenerative disorder that is caused by abnormal expansion of cag trinucleotide repeats. Chicago manual of style 16th edition full note american psychological association 6th edition. The disease is sometimes confused with chorea or st. Huntingtons disease hd is a hereditary brain disease, which disrupts thinking, mood, behavior, and movement. Please use one of the following formats to cite this article in your essay, paper or report. Huntington disease hd is an inherited progressive neurodegenerative disorder characterized by choreiform movements, psychiatric problems, and dementia. Huntingtons disease huntingtons disease bradley amos st. Huntingtons disease hd is caused by a dominant mutation that results in an unstable expansion of a cag repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with the disease. Huntingtons disease hd is a devastating genetic neurodegenerative disease caused by cag trinucleotide expansion in the exon1 region of the huntingtin gene. Huntingtons disease hd is a neurodegenerative disorder found throughout the world with an estimated global prevalence of 45 per million people in all ethnic groups, which makes it one of the most prevalent neurological orphan diseases, defined as a lifethreatening or chronically debilitating condition with a prevalence of less than 5 per 10,000 people.
Also, be sure in your intext citation to provide both the volume number and page number s see citing multivolume works on our intext citations resource. As the disease advances, uncoordinated, jerky body movements become more apparent. Prevalence in the caucasian population is estimated at 110,0001. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Huntington disease was one of the first neurological hereditary diseases for which genetic testing was made possible as early as 1993. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. It does not provide medical advice, diagnosis or treatment. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of hd, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of. Early symptoms of hd may include uncontrolled movements, clumsiness, and balance problems. It is caused by a trinucleotide cytosineadenineguanine cag expansion in the huntington gene on chromosome 4p and inherited in an autosomal dominant pattern.
Symptoms of the disease can vary aggression, anger, antisocial behavior, apathy, depression, excitement, frustration. Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble. Huntington disease hd is an inherited condition that causes progressive degeneration of neurons in the brain. The disease is sometimes confused with chorea chorea or st. However, formatting rules can vary widely between applications and fields of interest or study.
Understanding the role of genetics can help you recognize huntington disease in a patient with progressive motor disability. Genetic modifier for huntingtons disease progression. Huntingtons disease article about huntingtons disease. Nucleic acidbased therapy approaches for huntingtons disease. Huntingtons disease hd healthcare baylor college of. An inherited disorder characterized by neuronal dysfunction and degeneration in striatum and cerebral cortex. Researchers have developed a novel measure of disease progression for huntingtons disease, which enabled them to identify a genetic modifier associated with how rapidly the. As a result of the loss of death of brain cells, one suffering from huntingtons disease. The hereditary and debilitative nature of the disease means that many people are involved either directly or indirectly by this condition. Cite your book in american psychological association 6th edition format for free. Today, huntingtons disease is treatable, but it is still a devastating disease that has no cure, but researchers are working on longterm treatment for the disease. When citing more than one volume of a multivolume work, cite the total number of volumes in the work. George huntingtons on chorea inside huntingtons disease.
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